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An AI proposed a drug discovery fix. The wet lab ran 10,080 experiments to check. It held.

OpenAI's GPT-5.4 and Molecule.one's Maria AI ran a three-month chemistry collaboration and published the result June 17: AI proposed TEMPO as the fix for a difficult drug synthesis reaction; 10,080 physical wet-lab experiments later, the hypothesis survived. Average yield improved from 16.6% to 25.2%. This is the first publicly documented case of a frontier model driving a real wet-lab chemistry discovery.

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